immunotherapy using autoclaved l. major antigens and m. vaccae with meglumine antimoniate, for the treatment of experimental canine visceral leishmaniasis

Immunotherapy Using Autoclaved L. major Antigens and M. vaccae with Meglumine Antimoniate, for the Treatment of Experimental Canine Visceral Leishmaniasis

BACKGROUND To evaluate immunotherapy against canine visceral leishmaniasis, Leishmania major antigen and heat-killed Mycobacterium vaccae (SRL172) were used as stimulators of immune defense mechanisms and the results were compared with standard chemotherapy meglumine antimoniate. METHODS Nineteen mongrel dogs aging 1-3 years old were used in this experiment. Infection was carried out in 15 ou...

Efficacy of combined therapy with liposome-encapsulated meglumine antimoniate and allopurinol in treatment of canine visceral leishmaniasis.

An innovative liposomal formulation of meglumine antimoniate (LMA) was recently reported to promote both long-term parasite suppression and reduction of infectivity to sand flies in dogs with visceral leishmaniasis. However, 5 months after treatment, parasites were still found in the bone marrow of all treated dogs. In order to improve treatment with LMA, the present study aimed to evaluate its...

Field Trial of Autoclaved Leishmania Vaccines for Control of Canine Visceral Leishmaniasis in Meshkin-Shahr, Iran

Treatment of cutaneous leishmaniasis with combination of allopurinol and low dose of meglumine antimoniate

cutaneous leishmaniasis is one of the most prevalent endemic disease in Isfahan which is also hyperendemic in other parts of Iran.different treatment have been suddested for cutaneous Ieihmaniasis is glucantim and pentostam,however these drugs have significant side effects and can only be used intravenously.allopurinol is one of the oral medicines suggested for the treatment of cutaneous leishm...

omparative study of oral azithromycin and systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis

Background and aim: Complications and resistance to pentavalent antimonial agents in cutaneous leishmaniasis, exhibit the need for effective alternative drugs. The aim of this study was to compare the efficacy of oral azithromycin with systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis. Materials and Methods: Forty-seven patients with cutaneous leishmaniasis...

The effect of combination therapy with systemic Meglumine Antimoniate (Glucantime) and Pentoxifylline in the treatment of cutaneous Leishmaniasis

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